Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158375" target="_blank" >RIV/00098892:_____/23:10158375 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/23:E0110380 RIV/61988987:17110/23:A2402L1E RIV/61989100:27350/23:10252103 RIV/61989100:27360/23:10252103 RIV/61989100:27640/23:10252103
Result on the web
<a href="https://www.hh.um.es/Abstracts/Vol_38/38_10/38_10_1119.htm" target="_blank" >https://www.hh.um.es/Abstracts/Vol_38/38_10/38_10_1119.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14670/HH-18-606" target="_blank" >10.14670/HH-18-606</a>

Result language
angličtina
Original language name
Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb
Original language description
Fractured bones can regenerate and restore their biological and mechanical properties to the state prior to the damage. In some cases, however, the treatment of fractures requires the use of supportive implants. For bone healing, three processes are essential: the inflammatory phase, the repair phase and the remodelling phase. A proper course of the first - inflammatory stage is important to ensure a successful fracture healing process. In our study, we evaluated tissue samples immunohistochemically from the area surrounding the fractures of upper and lower limbs (bone tissue, soft tissue, and the implant-adhering tissue) for markers: CD11b, CD15, CD34, CD44, CD68, Cathepsin K, and TRAcP that are linked to the aforementioned phases. In soft tissue, higher expressions of CD68, CD34, CD15 and CD11b markers were observed than in other locations. TRAcP and Cathepsin K markers were more expressed in the bone tissue, while pigmentation, necrosis and calcification were more observed in the implant-adhering tissue. Since even the implant materials commonly perceived as inert elicit the observed inflammatory responses, new surface treatments and materials need to be developed.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30109 - Pathology

Project
<a href="/en/project/EF17_049%2F0008441" target="_blank" >EF17_049/0008441: Innovative therapeutic methods of musculoskeletal system in accident surgery</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)