Maternal and fetal outcomes in multiparous women with Cystic Fibrosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F24%3A10158641" target="_blank" >RIV/00098892:_____/24:10158641 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/24:73625748
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0954611124001288?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0954611124001288?pes=vor</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rmed.2024.107654" target="_blank" >10.1016/j.rmed.2024.107654</a>
Alternative languages
Result language
angličtina
Original language name
Maternal and fetal outcomes in multiparous women with Cystic Fibrosis
Original language description
Background: Quality of life and survival in Cystic Fibrosis (CF) have improved dramatically, making family planning a feasible option. Maternal and perinatal outcomes in women with CF (wwCF) are similar to those seen in the general population. However, the effect of undergoing multiple pregnancies is unknown. Methods: A multinational-multicenter retrospective cohort study. Data was obtained from 18 centers worldwide, anonymously, on wwCF 18–45 years old, including disease severity and outcome, as well as obstetric and newborn complications. Data were analyzed, within each individual patient to compare the outcomes of an initial pregnancy (1st or 2nd) with a multigravid pregnancy (≥3) as well as secondary analysis of grouped data to identify risk factors for disease progression or adverse neonatal outcomes. Three time periods were assessed – before, during, and after pregnancy. Results: The study population included 141 wwCF of whom 41 (29%) had ≥3 pregnancies, "multiparous". Data were collected on 246 pregnancies, between 1973 and 2020, 69 (28%) were multiparous. A greater decline in ppFEV1 was seen in multiparous women, primarily in pancreatic insufficient (PI) wwCF and those with two severe (class I-III) mutations. Multigravid pregnancies were shorter, especially in wwCF over 30 years old, who had high rates of prematurity and newborn complications. There was no effect on pulmonary exacerbations or disease-related complications. Conclusions: Multiple pregnancies in wwCF are associated with accelerated respiratory deterioration and higher rates of preterm births. Therefore, strict follow-up by a multidisciplinary CF and obstetric team is needed in women who desire to carry multiple pregnancies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Respiratory Medicine
ISSN
0954-6111
e-ISSN
1532-3064
Volume of the periodical
228
Issue of the periodical within the volume
July
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
107654
UT code for WoS article
001245932400001
EID of the result in the Scopus database
2-s2.0-85192944179