Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F24%3A10158702" target="_blank" >RIV/00098892:_____/24:10158702 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2072-6694/16/15/2630" target="_blank" >https://www.mdpi.com/2072-6694/16/15/2630</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers16152630" target="_blank" >10.3390/cancers16152630</a>

Result language

angličtina

Original language name

Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

Original language description

Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. The enzyme has usually been linked to T lymphocyte activation upon antigen recognition. Lck activation is central to CD4, CD8, and NK activation. However, recently, it has become clearer that activating the enzyme in CD8 cells can be independent of antigen presentation and enhance the cytotoxic response. The role of Lck in NK cytotoxic function has been controversial in a similar fashion as the role of the enzyme in CAR T cells. Inhibiting tyrosine kinases has been a highly successful approach to treating hematologic malignancies. The inhibitors may be useful in treating other tumor types, and they may be useful to prevent cell exhaustion. New, more selective inhibitors have been documented, and they have shown interesting activities not only in tumor growth but in the treatment of autoimmune diseases, asthma, and graft vs. host disease. Drug repurposing and bioinformatics can aid in solving several unsolved issues about the role of Lck in cancer. In summary, the role of Lck in immune response and tumor growth is not a simple event and requires more research.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/EH22_008%2F0004644" target="_blank" >EH22_008/0004644: Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

—

e-ISSN

2072-6694

Volume of the periodical

16

Issue of the periodical within the volume

15

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

2630

UT code for WoS article

001287077200001

EID of the result in the Scopus database

2-s2.0-85200834695