Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F24%3A10158725" target="_blank" >RIV/00098892:_____/24:10158725 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/24:73625902 RIV/61989100:27240/24:10257207
Result on the web
<a href="https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-04890-0" target="_blank" >https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-04890-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12887-024-04890-0" target="_blank" >10.1186/s12887-024-04890-0</a>
Alternative languages
Result language
angličtina
Original language name
Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease
Original language description
Background: Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. Methods: The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. Results: Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. Conclusions: Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Pediatrics
ISSN
1471-2431
e-ISSN
1471-2431
Volume of the periodical
24
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
426
UT code for WoS article
001262558200003
EID of the result in the Scopus database
2-s2.0-85197422144