Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159266" target="_blank" >RIV/00098892:_____/25:10159266 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/25:73631413
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/07853890.2025.2474175#abstract" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/07853890.2025.2474175#abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/07853890.2025.2474175" target="_blank" >10.1080/07853890.2025.2474175</a>

Result language
angličtina
Original language name
Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer
Original language description
From tumorigenesis to the establishment of local or metastatic high-grade tumours, an integral part of the cellular lifespan relies on various signalling pathways. Particular pathways that allow cells to proliferate by creating a network of new blood vessels have been documented, whereas other pathways are primarily involved with a migration to distant body parts, partially through the process of epithelial-mesenchymal transition (EMT). This review will discuss the different signalling pathways, such as TGF-β, Cripto-1, Wnt pathways, Hedgehog, Notch and NF-κB pathways, and how they promote tumour initiation and progression by influencing diverse cellular processes and EMT in general and in benign and malignant prostate tumours. This review will discuss only the critical pathways. Therefore, many other types of signalling pathways which are related to prostate cancer will not be discussed. Possibilities for further investigation will be mentioned, as many underlying mechanisms involved in these pathways have potential as targets in future tumour therapy. This review will also introduce some novel clinical trials relating to the inhibition of signalling pathways and their clinical outcomes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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