Rare germline ATM variants predispose to secondary cancer in chronic lymphocytic leukaemia patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159354" target="_blank" >RIV/00098892:_____/25:10159354 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/cac2.70010" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/cac2.70010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cac2.70010" target="_blank" >10.1002/cac2.70010</a>

Result language
angličtina
Original language name
Rare germline ATM variants predispose to secondary cancer in chronic lymphocytic leukaemia patients
Original language description
In this monocentric study, we aimed to assess whether patients with CLL carrying rare germline variants in ATM have a higher risk of familial CLL or a higher risk of cancer in first-degree relatives than patients without these variants. Next, we aimed to assess whether patients carrying rare ATM variants develop secondary cancer or develop CLL at an earlier age than patients without these variants, and whether these variants influence the time to first treatment (TTFT) and overall survival (OS) in patients with CLL. In this large cohort, we also sought to confirm our previous observation that rare variants in ATM are associated with the development of IGHV-unmutated CLL, which has a worse prognosis compared to IGHV-mutated disease.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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