Exploring the protective effects of soluble cytokinin salt p-topolin mesylate on skin through antioxidant activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159548" target="_blank" >RIV/00098892:_____/25:10159548 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2211715625008549?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2211715625008549?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rechem.2025.102870" target="_blank" >10.1016/j.rechem.2025.102870</a>
Alternative languages
Result language
angličtina
Original language name
Exploring the protective effects of soluble cytokinin salt p-topolin mesylate on skin through antioxidant activity
Original language description
Cytokinins, known as the compounds of natural origin, play a significant regulatory role in the senescence in plants. Several of them, such as 6-furfurylaminopurine (kinetin), also showed beneficial effects on human skin cells. We focused on structurally similar cytokinin 6-(4-hydroxybenzylamino)purine, p-topolin (pT), and its water-soluble mesylate salt (pTM). Newly prepared salt is 60 000 times more soluble in water than pT. Both compounds are UVA photostable, non-toxic and non-phototoxic. We also explored UVA protective effect on human fibroblasts (NHDF), keratinocytes (HaCaT) and porcine ear skin. Since the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway regulates various genes in regulation of oxidative stress, we focused on effects of pT and pTM in this manner. Both compounds increased translocation of Nrf2 transcription factor to the nucleus in NHDF and stimulated the accumulation of Bach1, a Nrf2 transcription regulator in HaCaT. Studied compounds also significantly reduced UVA-induced UPE (ultra-weak photon emission) related to reactive oxygen species (ROS) formation in skin cells and porcine ear skin ex vivo, in which pTM was found to have higher protective effect compared to pT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Results in Chemistry
ISSN
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e-ISSN
2211-7156
Volume of the periodical
18
Issue of the periodical within the volume
November
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
102870
UT code for WoS article
001617864700002
EID of the result in the Scopus database
2-s2.0-105021242811