Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and Eastern Europe

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F12%3A%230000867" target="_blank" >RIV/00159816:_____/12:#0000867 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/12:#0000647
Result on the web
<a href="http://dx.doi.org/10.1111/j.1747-4949.2011.00733.x" target="_blank" >http://dx.doi.org/10.1111/j.1747-4949.2011.00733.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1747-4949.2011.00733.x" target="_blank" >10.1111/j.1747-4949.2011.00733.x</a>

Result language
angličtina
Original language name
Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and Eastern Europe
Original language description
Background The current European license for alteplase in acute ischemic stroke excludes from treatment large groups of patients. Nevertheless, in everyday practice, many patients receive off-label thrombolysis at the physician's discretion. Aim Our aim was to evaluate safety and effectiveness of intravenous alteplase in patients not fully adhering to the drug license compared with those treated strictly according to the license in Central and Eastern Europe. Methods We analyzed the data contributed to Safe Implementation of Thrombolysis in Stroke registry from nine countries between February 2003 and February 2010. Statistical analysis included multivariate logistic regression.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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