Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F12%3A%230000951" target="_blank" >RIV/00159816:_____/12:#0000951 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/12:00065570
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2012.05.034" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2012.05.034</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2012.05.034" target="_blank" >10.1016/j.febslet.2012.05.034</a>
Alternative languages
Result language
angličtina
Original language name
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability
Original language description
The exact role of the central acidic domain of Mdm2 in p53 degradation remains unclear. We therefore performed a systematic and comprehensive analysis of the acidic domain using a series of short deletions and found that only a minor part of the domain was indispensable for Mdm2-mediated p53 ubiquitylation. Moreover, we identified a short stretch of acidic amino acids required for p53 degradation but not ubiquitylation, indicating that, in addition to p53 ubiquitylation, the acidic domain might be involved in a critical post-ubiquitylation step in p53 degradation. Rather than representing a single functional domain, different parts of the acidic region perform separate functions in p53 degradation, suggesting that it might be possible to therapeutically target them independently.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS LETTERS
ISSN
0014-5793
e-ISSN
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Volume of the periodical
586
Issue of the periodical within the volume
16
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
2225-2231
UT code for WoS article
000306694800004
EID of the result in the Scopus database
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