Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060552" target="_blank" >RIV/00159816:_____/13:00060552 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/13:00065634
Result on the web
<a href="http://www.hindawi.com/journals/mi/2013/342351/" target="_blank" >http://www.hindawi.com/journals/mi/2013/342351/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2013/342351" target="_blank" >10.1155/2013/342351</a>
Alternative languages
Result language
angličtina
Original language name
Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
Original language description
Objectives. Periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction. Interleukin-8 (IL8) is important in the regulation of the immune response. The aim of this study was to analyze four polymorphismsin the IL8 gene in relation to chronic (CP) and aggressive (AgP) periodontitis. Methods. A total of 492 unrelated subjects were included in this case-control association study. Genomic DNA of 278 patients with CP, 58 patients with AgP, and 156 controlswere genotyped, using the 5' nuclease TaqMan assay, for IL8 (rs4073, rs2227307, rs2227306, and rs2227532) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray detection kit in a subgroup of subjects (N = 247). Results. Allele and genotype frequencies of all investigated IL8 polymorphisms were not significantly different between the subjects with CP and/or AgP and controls (P > 0.05). Nevertheless, the A(-251)/T(+ 396)/T(+ 781) and T(-251)/G(+396)/
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11405" target="_blank" >NT11405: Microbiologic and genetic determinants of the onset and progression of periodontitis in type 1 and 2 diabetics and their reciprocal relationship to diabetes compensation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mediators of inflammation
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2013
Issue of the periodical within the volume
2013
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
000328429600001
EID of the result in the Scopus database
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