Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060572" target="_blank" >RIV/00159816:_____/13:00060572 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002908" target="_blank" >http://dx.doi.org/10.1161/STROKEAHA.113.002908</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002908" target="_blank" >10.1161/STROKEAHA.113.002908</a>

Result language
angličtina
Original language name
Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register
Original language description
Background and Purpose Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke ThrombolysisRegister. Methods A total of 45 079 patients treated with intravenous alteplase were recorded from 2002 to 2011. Main outcome measures were symptomatic intracerebral hemorrhage, functional independence (modified Rankin Scale score, 0-2), and mortality at3 months. Results Among 25 777 (57.2%) men and 19 302 (42.8%) women, we found no difference in the rate of symptomatic intracerebral hemorrhage (P=0.13), a significantly higher likelihood of functional independence at 3 months in men (P<
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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