Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060710" target="_blank" >RIV/00159816:_____/13:00060710 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00392583
Result on the web
<a href="http://dx.doi.org/10.3109/10715762.2012.747677" target="_blank" >http://dx.doi.org/10.3109/10715762.2012.747677</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10715762.2012.747677" target="_blank" >10.3109/10715762.2012.747677</a>
Alternative languages
Result language
angličtina
Original language name
Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production
Original language description
Endothelial dysfunction characterized by decreased nitric oxide (NO) bioavailability is the first stage of coronary artery disease. It is known that one of the factors associated with an increased risk of coronary artery disease is a high plasma level ofuric acid. However, causative associations between hyperuricaemia and cardiovascular risk have not been definitely proved. In this work, we tested the effect of uric acid on endothelial NO bioavailability. Electrochemical measurement of NO production inacetylcholine-stimulated human umbilical endothelial cells (HUVECs) revealed that uric acid markedly decreases NO release. This finding was confirmed by organ bath experiments on mouse aortic segments. Uric acid dose-dependently reduced endothelium-dependent vasorelaxation. To reveal the mechanism of decreasing NO bioavailability we tested the effect of uric acid on reactive oxygen species production by HUVECs, on arginase activity, and on acetylcholine-induced endothelial NO synthase p
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Free radical research
ISSN
1071-5762
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
82-88
UT code for WoS article
000313594600003
EID of the result in the Scopus database
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