Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060788" target="_blank" >RIV/00159816:_____/13:00060788 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1001/jamaneurol.2013.406" target="_blank" >http://dx.doi.org/10.1001/jamaneurol.2013.406</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1001/jamaneurol.2013.406" target="_blank" >10.1001/jamaneurol.2013.406</a>

Result language
angličtina
Original language name
Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study
Original language description
IMPORTANCE Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk. OBJECTIVE To compare the outcomes of patients who weretreated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic stroke with the outcomes of patients who were treated within 3 hours in the SITS-ISTR. DESIGN An observational study based on SITS-ISTR data during the period from 2002 to 2011. SETTING Acute and emergency care. PARTICIPANTS Of 29 618 patients with acute ischemic stroke, 283 (1.0%) were treated within 4.5 to 6 hours of onset, 4056 (13.7%) were within 3 to 4.5 hours of onset, and 25 279 (85.4%) were treated within 3 hoursof onset, in compliance with other European Union approval criteria. EXPOSURE Intravenous thrombolysis with alteplase. MAIN OUTCOMES AND MEASURES Functional independence (modified Rankin Scale score of 0-2) and mortality at 3 months and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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