Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060816" target="_blank" >RIV/00159816:_____/13:00060816 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4161/jkst.23810" target="_blank" >http://dx.doi.org/10.4161/jkst.23810</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/jkst.23810" target="_blank" >10.4161/jkst.23810</a>

Result language

angličtina

Original language name

Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

Original language description

Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.(1) As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-beta-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful mole

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JAK-STAT

ISSN

2162-3988

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

"e23810"

UT code for WoS article

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EID of the result in the Scopus database

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