From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00063519" target="_blank" >RIV/00159816:_____/13:00063519 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/13:00212729 RIV/00216305:26220/13:PU105353
Result on the web
<a href="http://dx.doi.org/10.2174/18715206113139990304" target="_blank" >http://dx.doi.org/10.2174/18715206113139990304</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/18715206113139990304" target="_blank" >10.2174/18715206113139990304</a>

Result language
angličtina
Original language name
From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment
Original language description
The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action isvery complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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