Nucleases in homologous recombination as targets for cancer therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061104" target="_blank" >RIV/00159816:_____/14:00061104 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00073831
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2014.06.010" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2014.06.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2014.06.010" target="_blank" >10.1016/j.febslet.2014.06.010</a>
Alternative languages
Result language
angličtina
Original language name
Nucleases in homologous recombination as targets for cancer therapy
Original language description
Genomic DNA is constantly challenged from endogenous as well as exogenous sources. The DNA damage response (DDR) mechanism has evolved to combat these challenges and ensure genomic integrity. In this review, we will focus on repair of DNA double-strand breaks (DSB) by homologous recombination and the role of several nucleases and other recombination factors as suitable targets for cancer therapy. Their inactivation as well as overexpression have been shown to sensitize cancer cells by increasing toxicity to DNA-damaging agents and radiation or to be responsible for resistance of cancer cells. These factors can also be used in targeted cancer therapy by taking advantage of specific genetic abnormalities of cancer cells that are not present in normal cells and that result in cancer cell lethality.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
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Volume of the periodical
588
Issue of the periodical within the volume
15
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
2446-2456
UT code for WoS article
000339535200013
EID of the result in the Scopus database
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