Chemoreflexes, sleep apnea, and sympathetic dysregulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061165" target="_blank" >RIV/00159816:_____/14:00061165 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s11906-014-0476-2" target="_blank" >http://dx.doi.org/10.1007/s11906-014-0476-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11906-014-0476-2" target="_blank" >10.1007/s11906-014-0476-2</a>

Result language

angličtina

Original language name

Chemoreflexes, sleep apnea, and sympathetic dysregulation

Original language description

Obstructive sleep apnea (OSA) and hypertension are closely linked conditions. Disordered breathing events in OSA are characterized by increasing efforts against an occluded airway while asleep, resulting in a marked sympathetic response. This is predominantly due to hypoxemia activating the chemoreflexes, resulting in reflex increases in sympathetic neural outflow. In addition, apnea - and the consequent lack of inhibition of the sympathetic system that occurs with lung inflation during normal breathing- potentiates central sympathetic outflow. Sympathetic activation persists into the daytime, and is thought to contribute to hypertension and other adverse cardiovascular outcomes. This review discusses chemoreflex physiology and sympathetic modulationduring normal sleep, as well as the sympathetic dysregulation seen in OSA, its extension into wakefulness, and changes after treatment. Evidence supporting the role of the peripheral chemoreflex in the sympathetic dysregulation seen in OS

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Hypertension Reports

ISSN

1522-6417

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

476

UT code for WoS article

000341428700011

EID of the result in the Scopus database

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