Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061205" target="_blank" >RIV/00159816:_____/14:00061205 - isvavai.cz</a>

Result on the web

<a href="http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00219/full" target="_blank" >http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00219/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2014.00219" target="_blank" >10.3389/fphys.2014.00219</a>

Result language

angličtina

Original language name

Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function

Original language description

The identification of different pools of cardiac progenitor cells resident in the adult mammalian heart opened a new era in heart regeneration as a means to restore the loss of functional cardiac tissue and overcome the limited availability of donor organs. Indeed, resident stem cells are believed to participate to tissue homeostasis and renewal in healthy and damaged myocardium although their actual contribution to these processes remain unclear. The poor outcome in terms of cardiac regeneration following tissue damage point out at the need for a deeper understanding of the molecular mechanisms controlling CPC behavior and fate determination before new therapeutic strategies can be developed. The regulation of cardiac resident stem cell fate and function is likely to result from the interplay between pleiotropic signaling pathways as well as tissue- and cell-specific regulators. Such a modular interaction-which has already been described in the nucleus of a number of different cells w

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physiology

ISSN

1664-042X

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

July

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

219

UT code for WoS article

000347068100001

EID of the result in the Scopus database

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