Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061213" target="_blank" >RIV/00159816:_____/14:00061213 - isvavai.cz</a>

Alternative codes found

RIV/00209775:_____/14:#0000294

Result on the web

<a href="http://dx.doi.org/10.2217/bmm.14.38" target="_blank" >http://dx.doi.org/10.2217/bmm.14.38</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/bmm.14.38" target="_blank" >10.2217/bmm.14.38</a>

Result language

angličtina

Original language name

Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives

Original language description

Aortic dissection (AD) is a severe vascular disease associated with major morbidity and mortality. The diagnosis of AD requires the performance of urgent aortic imaging exams such as computed tomography angiography, but the decision to perform these exams now essentially relies on clinical judgment. Several studies have identified a range of potential biomarkers stemming from the aortic extracellular matrix (matrix metalloproteinases, TGF-beta, soluble elastin fragments), vascular smooth muscle cells (smooth muscle myosin heavy chain, creatine kinase, calponin), coagulation (d-dimer, platelets) and inflammation (C-reactive protein), whose circulating levels increase in patients affected by AD. Biomarkers of AD could be potentially used to screen patients with compatible symptoms, to identify patients at higher risk of AD, to rule out AD in patients with non-high clinical probability of AD and/or to obtain prognostic stratification of affected patients. This review will summarize availa

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomarkers in Medicine

ISSN

1752-0363

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

931-41

UT code for WoS article

000343183100003

EID of the result in the Scopus database

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