Evaluation of a novel vascular graft with a distal bifurcation designed to reduce tne development of intimal hyperplasia. Experimental study in a porcine aorta model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061308" target="_blank" >RIV/00159816:_____/14:00061308 - isvavai.cz</a>

Result on the web

<a href="http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=518&type=fin&ver=3" target="_blank" >http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=518&type=fin&ver=3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2013.021" target="_blank" >10.5507/bp.2013.021</a>

Result language

angličtina

Original language name

Evaluation of a novel vascular graft with a distal bifurcation designed to reduce tne development of intimal hyperplasia. Experimental study in a porcine aorta model

Original language description

Abnormal haemodynamics is commonly agreed to be a major contributor to the development of distal anastomotic intimal hyperplasia. A new vascular graft design proposed by computational studies was used to demonstrate its surgical feasibility and to compare it with the conventional graft in a porcine model. Method: The device was used in 12 eight-month-old pigs, six received the new graft and six had a conventional graft. The proximal graft end was implanted into the aorta, the distal graft end was implanted into the iliac artery. The host artery was ligated in order to simulate occlusion. At 20 weeks after surgery the pigs were killed and the device was excised for histological and morphometric analysis. Results: In five experimental grafts the reconstruction was occluded due to thrombosis; only one prosthesis was patent showing a minimum of neointimal hyperplasia. In the control group too only three of the six grafts were patent. A histological analysis revealed, as the cause of occlusion, fibrous tissue overgrowth corresponding in structure to neointimal hyperplasia. Differences in the number of obliterations and in occlusion rates between the profiles of the two groups were evaluated using the median test (P<0.05). The results were not statistically significant. Conclusion: Although mathematical modelling had shown significant haemodynamic benefits of a naturally bifurcated graft, our study did not confirm its superiority over conventionally used prostheses.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

158

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

562-568

UT code for WoS article

000347173200011

EID of the result in the Scopus database

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