Increased salt intake during early ontogenesis lead to development of arterial hypertension in salt-resistant Wistar rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00061097" target="_blank" >RIV/00159816:_____/15:00061097 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10641963.2014.913610" target="_blank" >http://dx.doi.org/10.3109/10641963.2014.913610</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10641963.2014.913610" target="_blank" >10.3109/10641963.2014.913610</a>
Alternative languages
Result language
angličtina
Original language name
Increased salt intake during early ontogenesis lead to development of arterial hypertension in salt-resistant Wistar rats
Original language description
A direct relationship exists between salt consumption and hypertension. Increased sodium intake does not automatically lead to a rise in blood pressure (BP) because of marked intra-individual variability in salt sensitivity. Wistar rats are a salt-resistant strain and increased salt intake in adults does not induce hypertension. Mechanisms regulating BP develop during early ontogenesis and increased sodium consumption by pregnant females leads to an increase in BP of their offspring, but early postnatalstages have not been sufficiently analyzed in salt-resistant strains of rats. The aim of this work was to study the effects of increased salt during early ontogeny on cardiovascular characteristics of Wistar rats. We used 16 control (C; 8 males + 8 females) rats fed with a standard diet (0.2% sodium) and 16 experimental (S; 8 males + 8 females) rats fed with a diet containing 0.8% sodium. BP was measured weekly and plasma renin activity, aldosterone and testosterone concentrations were
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Hypertension
ISSN
1064-1963
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
142-147
UT code for WoS article
000351382300009
EID of the result in the Scopus database
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