Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063065" target="_blank" >RIV/00159816:_____/15:00063065 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/15:00455893

Result on the web

<a href="http://dx.doi.org/10.1016/j.vph.2015.06.005" target="_blank" >http://dx.doi.org/10.1016/j.vph.2015.06.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vph.2015.06.005" target="_blank" >10.1016/j.vph.2015.06.005</a>

Result language

angličtina

Original language name

Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha

Original language description

Pulmonary hypertension (PH), associated with imbalance in vasoactive mediators and massive remodeling of pulmonary vasculature, represents a serious health complication. Despite the progress in treatment, PH patients typically have poor prognoses with severely affected quality of life. Asymmetric dimethyl arginine (ADMA), endogenous inhibitor of endothelial nitric oxide synthase (eNOS), also represents one of the critical regulators of pulmonary vascular functions. The present study describes a novel mechanism of ADMA-induced dysfunction in human pulmonary endothelial and smooth muscle cells. The effect of ADMA was compared with well-established model of hypoxia-induced pulmonary vascular dysfunction. It was discovered for the first time that ADMA induced the activation of signal transducer and activator of transcription 3 (STAT3) and stabilization of hypoxia inducible factor 1? (HIF-1?) in both types of cells, associated with drastic alternations in normal cellular functions (e.g., ni

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vascular Pharmacology

ISSN

1537-1891

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

OCT

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

138-148

UT code for WoS article

000362056600018

EID of the result in the Scopus database

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