Polymorphisms of the Peroxisome Proliferator-Activated Receptor-gamma (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063205" target="_blank" >RIV/00159816:_____/15:00063205 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12933-015-0197-0" target="_blank" >http://dx.doi.org/10.1186/s12933-015-0197-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12933-015-0197-0" target="_blank" >10.1186/s12933-015-0197-0</a>

Result language
angličtina
Original language name
Polymorphisms of the Peroxisome Proliferator-Activated Receptor-gamma (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus
Original language description
The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 (PGC-1alpha) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM. Methods: Two exonic SNPs of both genes rs1801282 of the PPAR-gamma gene and rs8192673 of the PGC-1 alpha gene) were genotyped in 881 unrelated Slovene subjects (Caucasians) with T2DM and in 348 subjects without T2DM (control subjects). Results: Female homozygotes with the CC genotype of the rs8192673 had higher waist circumference in comparison with subjects with other genotypes. Homozygotes (females, males) with wild allele (Pro) of the rs1801282 (Pro12Ala polymorphism) had higher waist circumference in
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—

Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)