Impact of dabigatran on platelet function and fibrinolysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063324" target="_blank" >RIV/00159816:_____/15:00063324 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jns.2015.07.031" target="_blank" >http://dx.doi.org/10.1016/j.jns.2015.07.031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2015.07.031" target="_blank" >10.1016/j.jns.2015.07.031</a>

Result language
angličtina
Original language name
Impact of dabigatran on platelet function and fibrinolysis
Original language description
Background: We sought to evaluate the potential enhanced fibrinolytic and antiplatelet activity of dabigatran etexilate (DE) due to decreased thrombin levels in patients with stroke or transient ischemic attack and non-valvular atrial fibrillation (NVAF). Methods: Consecutive patients with cerebrovascular diseases and NVAF that were treated with DE in a tertiary university hospital. Fibrinolysis and platelet function were assessed by thromboelastometry (ROTEM) and platelet function analyzer (PFA)-100, respectively, before and after treatment with DE. Conventional coagulation tests, endogenous thrombin potential (ETP) and hemoclot thrombin inhibitors (HTI), were also performed in order to detect any possible correlation between dabigatran plasma levels,its anticoagulant activity and the intensity of platelet dysfunction or fibrinolysis. Results: A total of nineteen patients fulfilled our inclusion criteria (mean age 623 +/- 7.2 years; 47% males; median CHADS2-score: 3; interquartile ra
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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