Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063743" target="_blank" >RIV/00159816:_____/15:00063743 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/joic.12251" target="_blank" >http://dx.doi.org/10.1111/joic.12251</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/joic.12251" target="_blank" >10.1111/joic.12251</a>

Result language
angličtina
Original language name
Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI
Original language description
Background: Bleeding after percutaneous coronary interventions (PCI) is an important complication with impact on prognosis. Aim: To evaluate the predictive value of enhanced platelet responsiveness to dual antiplatelet therapy with aspirin and clopidogrel, for bleeding, after elective PCI. Methods and Results: We performed multiple electrode aggregometry (MAE) platelet functional tests induced by arachidonic acid (ASPI) and adenosine-diphosphate (ADP) before PCI, and 24 hours after PCI, in 481 electivePCI patients who were followed-up for an average of 15.34 +/- 7.19 months. Primary end point was the occurrence of any bleeding, while ischemic major adverse cardiovascular event (MACE) was a secondary endpoint. The incidence of total, BARC {= 2, and BARC }= 3 bleeding, according to BARC classification, was 19, 18, and 1%, respectively. Groups with any, and BARC {= 2 bleeding, had a lower average value of MAE ADP test after 24 hours, compared to the group without bleeding: 45.30 +/- 18.6
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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