Safety of Intravenous Thrombolysis among Stroke Patients Taking New Oral Anticoagulants-Case Series and Systematic Review of Reported Cases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00064387" target="_blank" >RIV/00159816:_____/15:00064387 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.07.021" target="_blank" >http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.07.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.07.021" target="_blank" >10.1016/j.jstrokecerebrovasdis.2015.07.021</a>

Result language
angličtina
Original language name
Safety of Intravenous Thrombolysis among Stroke Patients Taking New Oral Anticoagulants-Case Series and Systematic Review of Reported Cases
Original language description
Background: Current guidelines do not recommend the administration of intravenous tissue plasminogen activator (IV-tPA) to patients with acute ischemic stroke (AIS) who take new oral anticoagulants (NOACs). We present a multicenter case series of IV-tPAuse while the patients are on NOACs, as well as a systematic review of the literature. Methods: We reviewed the medical records of consecutive patients on NOACs who received IV-tPA for symptoms of AIS at four participating stroke centers in the United States and Europe. Safety endpoints were post-thrombolysis symptomatic intracranial hemorrhage (sICH) or other serious systemic bleeding. Results: Between October 2010 and October 2014, 6 patients received IV-tPA for possible AIS while taking dabigatran. None of the patients had sICH or any other hemorrhagic complication. Literature review resulted in a total of 26 patients receiving IV-tPA while on NOACs (dabigatran: 15, rivaroxaban: 10, apixaban: 1). Among them, two patients experienced
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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