Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00065640" target="_blank" >RIV/00159816:_____/15:00065640 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/15:00090186
Result on the web
<a href="https://www.degruyter.com/view/j/bjmg.2015.18.issue-2/bjmg-2015-0084/bjmg-2015-0084.xml" target="_blank" >https://www.degruyter.com/view/j/bjmg.2015.18.issue-2/bjmg-2015-0084/bjmg-2015-0084.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/bjmg-2015-0084" target="_blank" >10.1515/bjmg-2015-0084</a>

Result language
angličtina
Original language name
Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus
Original language description
The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)