Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00063950" target="_blank" >RIV/00159816:_____/16:00063950 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00089280 RIV/65269705:_____/16:00063950

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs13760-015-0596-8" target="_blank" >http://link.springer.com/article/10.1007%2Fs13760-015-0596-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13760-015-0596-8" target="_blank" >10.1007/s13760-015-0596-8</a>

Result language

angličtina

Original language name

Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis

Original language description

Abstract Limited evidence suggests that specificity of cardiac troponin T (cTnT), a highly sensitive biomarker of myocardial injury, is reduced in patients with skeletal myopathies. Whether amyotrophic lateral sclerosis (ALS)-the most common motor neuron disease-could be also associated with abnormal plasma or serum cTnT levels remains unclear. Our objective was to assess cTnT levels in patients with ALS without known cTnT elevating conditions. Among ALS patients seen at our institution until 2012 we identified those who had their cTnT measured. Patients who suffered from conditions known to elevate cTnT were excluded. A case-control analysis comparing cTnT levels of these ALS patients to matched non-ALS controls fulfilling the same inclusion criteria was performed. We included 40 ALS patients of whom 27 (68 %) patients had a positive cTnT. In the control group (n = 40), 2 (5 %) tested as cTnT positive (p.001). Among the ALS patients who underwent cTnT evaluation on more occasions (n = 7; median followup = 1.08 years), 2 (29 %) patients tested positive during the initial measurement while 6 (86 %) of them had positive cTnT at the subsequent evaluations. ALS patients with increased cTnT had been diagnosed with ALS significantly earlier than those without the elevation. Our findings raise the possibility that ALS may cause cTnT elevations. Further studies are needed to confirm these findings, clarify the pathophysiological mechanism, and establish the significance of cTnT elevations in patients with ALS.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurologica Belgica

ISSN

0300-9009

e-ISSN

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Volume of the periodical

116

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

557-564

UT code for WoS article

000387681300019

EID of the result in the Scopus database

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