Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00064080" target="_blank" >RIV/00159816:_____/16:00064080 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00092193 RIV/65269705:_____/16:00064080 RIV/00209805:_____/16:N0000069

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S2213158216300389" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2213158216300389</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2016.02.016" target="_blank" >10.1016/j.nicl.2016.02.016</a>

Result language

angličtina

Original language name

Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging

Original language description

The accurate identification of glioblastoma progression remains an unmet clinical need. The aim of this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy (MRS) and the values of the apparent diffusion coefficient (ADC) to enable distinguishing tumor recurrence from pseudoprogression. Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence - median time to progression was 6.7 months. The highest significant sensitivity and specificity to call the glioblastoma recurrence was observed for the total choline (tCho) to total N-acetylaspartate (tNAA) concentration ratio with the threshold GREATER-THAN OR EQUAL TO 1.3 (sensitivity 100.0% and specificity 94.7%). The ADCmean value higher than 1313 x 10MINUS SIGN 6 mm2/s was associated with the pseudoprogression (sensitivity 98.3%, specificity 100.0%). The combination of MRS focused on the tCho/tNAA concentration ratio and the ADCmean value represents imaging methods applicable to early non-invasive differentiation between a glioblastoma recurrence and a pseudoprogression. However, the institutional definition and validation of thresholds for differential diagnostics is needed for elimination of setup errors before implementation of these multimodal imaging techniques into clinical practice, as well as into clinical trials.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NeuroImage-Clinical

ISSN

2213-1582

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

316-321

UT code for WoS article

000379504500035

EID of the result in the Scopus database

—