Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065035" target="_blank" >RIV/00159816:_____/16:00065035 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1586/14737175.2016.1168297" target="_blank" >http://dx.doi.org/10.1586/14737175.2016.1168297</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1586/14737175.2016.1168297" target="_blank" >10.1586/14737175.2016.1168297</a>

Result language

angličtina

Original language name

Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence

Original language description

BACKGROUND: Ischemic stroke is a major cause of death and disability and intravenous thrombolysis has been the only approved acute reperfusion therapy (RT) for many years. METHODS: Seven randomized-controlled clinical trials (RCTs) evaluating the safety and efficacy of endovascular therapy in patients with acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) have been recently published. RESULTS: These studies have changed the treatment paradigm by establishing mechanical thrombectomy (MT) as the most effective acute stroke therapy for improving functional outcome in anterior circulation ELVO with a NNT of 6. CONCLUSIONS: The present review will critically evaluate the results of these RCTs and of the existing meta-analyses investigating the safety and efficacy of endovascular therapy for AIS. Points of debate such as acute stroke imaging, posterior circulation stroke and general anesthesia will be addressed. We will also discuss health policies aiming to increase the availability of endovascular treatment for stroke patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Expert Review of Neurotherapeutics

ISSN

1473-7175

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

527-534

UT code for WoS article

000374950900008

EID of the result in the Scopus database

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