Measurement of transepidermal water loss in localized scleroderma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065348" target="_blank" >RIV/00159816:_____/16:00065348 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00090529

Result on the web

<a href="http://dx.doi.org/10.1111/dth.12339" target="_blank" >http://dx.doi.org/10.1111/dth.12339</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/dth.12339" target="_blank" >10.1111/dth.12339</a>

Result language

angličtina

Original language name

Measurement of transepidermal water loss in localized scleroderma

Original language description

Localized scleroderma (LS) is a disease characterized by fibrotic changes in the dermis. Connective tissue growth factor and transforming growth factor β2 are the main mediators of fibrogenesis; this, along with excessive connective tissue production, affects epidermal keratinocytes, and thereby contributes to the changed quality of skin barrier. The objective of this article was to study the objective measurement of the skin barrier quality in LS with transepidermal water loss (TEWL) meter. The measurements of TEWL were performed on LS plaques in all three stages of various body locations. Control measurements were made on the contralateral side of healthy skin. The difference between TEWL in LS area and the contralateral side of the healthy skin was evaluated. A higher average TEWL 7.86 g/m2/h (SD 5.29) was observed on LS plaques compared with the control measurements on healthy skin 6.39 g/m2/h (SD 2.77). TEWL average values decreased from the inflammatory stage, through the sclerotic and to the atrophic stage. The mean difference 1.301 g/m2/h (SD 5.16) was found between TEWL on LS plaques and on the contralateral healthy skin in 82 measurements, i.e., a higher TEWL was observed in LS. The difference was statistically significant with p = 0.0250. Although fibrogenesis in scleroderma is localized in dermis, the skin barrier changes can be detected.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dermatologic Therapy

ISSN

1396-0296

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

177-180

UT code for WoS article

000377257300010

EID of the result in the Scopus database

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