Interictal high-frequency oscillations in focal human epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065362" target="_blank" >RIV/00159816:_____/16:00065362 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26220/16:PU119223
Result on the web
<a href="http://dx.doi.org/10.1097/WCO.0000000000000302" target="_blank" >http://dx.doi.org/10.1097/WCO.0000000000000302</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/WCO.0000000000000302" target="_blank" >10.1097/WCO.0000000000000302</a>
Alternative languages
Result language
angličtina
Original language name
Interictal high-frequency oscillations in focal human epilepsy
Original language description
Purpose of reviewLocalization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers.Recent findingsPerforming the PubMed search High-Frequency Oscillations and Epilepsy' for 2013-2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications.SummaryThere is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Neurology
ISSN
1350-7540
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
175-181
UT code for WoS article
000371903100010
EID of the result in the Scopus database
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