Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065558" target="_blank" >RIV/00159816:_____/16:00065558 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/16:00065558 RIV/00216224:14310/16:00088884
Result on the web
<a href="http://dx.doi.org/10.3233/CBM-160623" target="_blank" >http://dx.doi.org/10.3233/CBM-160623</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CBM-160623" target="_blank" >10.3233/CBM-160623</a>
Alternative languages
Result language
angličtina
Original language name
Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas
Original language description
BACKGROUND: Nestin, CD133 and ABCG2 are recently discussed as putative markers, co-expression of which might determine a cancer stem cell (CSC) phenotype in sarcomas. OBJECTIVE: Our study is focused on immunohistochemical analysis of nestin, CD133 and ABCG2 expression in rhabdomyosarcoma, Ewing sarcoma and osteosarcoma. Furthermore, we also analyzed the possible correlation of nestin, CD133 and ABCG2 expression levels with the patient outcome to identify potential prognostic values of these three putative CSC markers in the same cohorts. METHODS: Using immunohistochemistry, expression of nestin, CD133 and ABCG2 was analyzed in 24 rhabdomyosarcoma, 22 Ewing sarcoma and 10 osteosarcoma tissue samples and expression levels of these markers were correlated with clinical outcome. RESULTS: High nestin levels indicate poor prognosis in patients with Ewing sarcoma (P = 0.001), and high CD133 expression is associated with shorter survival in rhabdomyosarcoma patients (P = 0.002). In contrast, no significant relationship was found between ABCG2 expression and the clinical outcome. CONCLUSIONS: Our analysis represents the first complex study of these three putative CSCsmarkers together in three different types of pediatric sarcomas and showed their possible prognostic values in these tumors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Biomarkers
ISSN
1574-0153
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
107-116
UT code for WoS article
000381114300014
EID of the result in the Scopus database
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