Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065636" target="_blank" >RIV/00159816:_____/16:00065636 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/acps.12630" target="_blank" >http://dx.doi.org/10.1111/acps.12630</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/acps.12630" target="_blank" >10.1111/acps.12630</a>

Result language

angličtina

Original language name

Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry

Original language description

Background The association between mortality risk and use of antidepressants in people with dementia is unknown. Objective To describe the use of antidepressants in people with different dementia diagnoses and to explore mortality risk associated with use of antidepressants 3 years before a dementia diagnosis. Methods Study population included 20 050 memory clinic patients from the Swedish Dementia Registry (SveDem) diagnosed with incident dementia. Data on antidepressants dispensed at the time of dementia diagnosis and during 3-year period before dementia diagnosis were obtained from the Swedish Prescribed Drug Register. Cox regression models were used. Results During a median follow-up of 2 years from dementia diagnosis, 25.8% of dementia patients died. A quarter (25.0%) of patients were on antidepressants at the time of dementia diagnosis, while 21.6% used antidepressants at some point during a 3-year period before a dementia diagnosis. Use of antidepressant treatment for 3 consecutive years before a dementia diagnosis was associated with a lower mortality risk for all dementia disorders and in Alzheimer's disease. Conclusion Antidepressant treatment is common among patients with dementia. Use of antidepressants during prodromal stages may reduce mortality in dementia and specifically in Alzheimer's disease.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Psychiatrica Scandinavica

ISSN

0001-690X

e-ISSN

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Volume of the periodical

134

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

430-440

UT code for WoS article

000387851800007

EID of the result in the Scopus database

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