Model Of Telomere Shortening And Immunosenescence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066035" target="_blank" >RIV/00159816:_____/16:00066035 - isvavai.cz</a>
Result on the web
<a href="http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf" target="_blank" >http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Model Of Telomere Shortening And Immunosenescence
Original language description
The immune system is the defence mechanism aimed to combat pathogens as well as damaged self-cells. Age-associated immune dysfunction also termed 'immunosenescence', is a common phenomenon responsible for susceptibility to numerous diseases (Hornsby, 2007; Ponnappan & Ponnappan, 2011). Intensive research has been conducted recently to understand the phenotypic and functional defects caused by aging within the human immune system. However, a clear understanding of the immune system aging and its molecular and cellular mechanisms remains mostly unknown. One of the major hallmarks of aging process is telomere shortening. Functional component of human telomerase reverse transcriptase (hTERT) was silenced in the cell line of induced pluripotent stem cells using siRNA. Changes in hTERT expression were analyzed using qPCR and changes in total length of telomeres were analyzed from genomic DNA. We have established model where we can experimentally modulate the control of telomere elongation mechanism in human induced pluripotent stem cells. This tool can be used for further analysis of molecular mechanism of aging processes.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Stárnutí 2016 Sborník příspěvků 3. gerontologické mezioborové konference
ISBN
978-80-87878-23-1
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
84-87
Publisher name
3. lékařská fakulta Univerzity Karlovy
Place of publication
Praha
Event location
Praha
Event date
Oct 19, 2016
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000392695400011

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