MECHANOSENSING PROTEINS YAP/TAZ DYNAMICALLY CONTROL CARDIAC CELL MATURATION AND FUNCTION BY SENSING ECM NANOTOPOGRAPHY

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066037" target="_blank" >RIV/00159816:_____/16:00066037 - isvavai.cz</a>
Result on the web
<a href="https://www.nanocon.eu/cz/o-konferenci-historie-sborniky-foto/2016/" target="_blank" >https://www.nanocon.eu/cz/o-konferenci-historie-sborniky-foto/2016/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
MECHANOSENSING PROTEINS YAP/TAZ DYNAMICALLY CONTROL CARDIAC CELL MATURATION AND FUNCTION BY SENSING ECM NANOTOPOGRAPHY
Original language description
The composition and arrangement of extracellular matrix (ECM) components in adult cardiac tissue plays a key role in the organization and alignment of synchronously and functionally beating cardiomyocytes. Following Heart failure (HF) - the end stage of cardiac pathologies in which cardiac muscle is not able to pump adequate blood to the organism - critical changes in mechanics and nanotopography occur along with the composition of cardiac ECM. Such modifications in ECM compliance and nanotopography - collectively defined as remodelling - are deemed to hinder local cell viability and function. At the moment, reliable in vitro models of the dynamic modifications occurring in vivo during cardiac remodelling process are missing. The Mechanosensing pathway Hippo acts through its effectors YAP/TAZ and is sensitive to changes in ECM mechanical properties. In the present study we demonstrate that, while being responsive to substrate compliance in a pathophysiological range (0.3-40 kPa), the nuclear localization and transcriptional activity of YAP/TAZ can be tuned by dynamical modifications of surface mechanics and nanotopography, as demonstrated by ad hoc developed thermo-responsive polymers displaying shape-memory properties.
Czech name
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Czech description
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Project
<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
8TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2016)
ISBN
978-80-87294-71-0
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
419-423
Publisher name
TANGER LTD
Place of publication
Ostrava
Event location
Brno
Event date
Oct 19, 2016
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000410656100073

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