Genetic risk factors of cisplatin induced ototoxicity in adult patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066277" target="_blank" >RIV/00159816:_____/16:00066277 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00088880 RIV/00209805:_____/16:N0000093

Result on the web

<a href="http://dx.doi.org/10.4149/212_140820N391" target="_blank" >http://dx.doi.org/10.4149/212_140820N391</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/212_140820N391" target="_blank" >10.4149/212_140820N391</a>

Result language

angličtina

Original language name

Genetic risk factors of cisplatin induced ototoxicity in adult patients

Original language description

Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

<a href="/en/project/NS10101" target="_blank" >NS10101: Genetic aspects of the cisplatin induced ototoxicity - the prospective association study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

263-268

UT code for WoS article

000375340400012

EID of the result in the Scopus database

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