USEFULNESS OF NT-proBNP IN THE FOLLOW-UP OF PATIENTS AFTER MYOCARDIAL INFARCTION

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00068470" target="_blank" >RIV/00159816:_____/16:00068470 - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346793/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346793/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/jomb-2016-0003" target="_blank" >10.1515/jomb-2016-0003</a>

Result language

angličtina

Original language name

USEFULNESS OF NT-proBNP IN THE FOLLOW-UP OF PATIENTS AFTER MYOCARDIAL INFARCTION

Original language description

Background: Since serial analyses of NT-proBNP in patients with acute coronary syndromes have shown that levels measured during a chronic, later phase are a better predictor of prognosis and indicator of left ventricular function than the levels measured during an acute phase, we sought to assess the association of NT-proBNP, measured 6 months after acute myocardial infarction (AMI), with traditional risk factors, characteristics of in-hospital and early postinfarction course, as well as its prognostic value and optimal cut-points in the ensuing 1-year follow-up. Methods: Fasting venous blood samples were drawn from 100 ambulatory patients and NT-proBNP concentrations in lithium-heparin plasma were determined using a one-step enzyme immunoassay based on the &quot;sandwich&quot; principle on a Dimension RxL clinical chemistry system (DADE Behring-Siemens). Patients were followed-up for the next 1 year, for the occurrence of new cardiac events. Results: Median (IQR) level of NT-proBNP was 521 (3351095) pg/mL. Highest values were mostly associated with cardiac events during the first 6 months after AMI. Negative association with reperfusion therapy for index infarction confirmed its long-term beneficial effect. In the next one-year follow-up of stable patients, multivariate Cox regression analysis revealed the independent prognostic value of NT-proBNP for new-onset heart failure prediction (p=0.014), as well as for new coronary events prediction (p=0.035). Calculation of the AUCs revealed the optimal NT-proBNP cut-points of 800 pg/mL and 516 pg/mL, respectively. Conclusions: NT-proBNP values 6 months after AMI are mainly associated with the characteristics of early infarction and postinfarction course and can predict new cardiac events in the next one-year follow-up.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF MEDICAL BIOCHEMISTRY

ISSN

1452-8258

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

158-165

UT code for WoS article

000375745000009

EID of the result in the Scopus database

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