Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066799" target="_blank" >RIV/00159816:_____/17:00066799 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/17:00066799 RIV/00216224:14110/17:00095701
Result on the web
<a href="https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3115-x" target="_blank" >https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3115-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12885-017-3115-x" target="_blank" >10.1186/s12885-017-3115-x</a>

Result language
angličtina
Original language name
Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene
Original language description
Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement. The standard of care is surgical resection. Observations suggest that low dose chemotherapy is beneficial. The treatment of resistant or relapsed patients with multifocal disease remains challenging. Patients that harbor an actionable mutation in the kinase domain are potential subjects for targeted tyrosine kinase inhibitor therapy.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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