Permeability surface area product analysis in malignant brain edema prediction – A pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066850" target="_blank" >RIV/00159816:_____/17:00066850 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00096427

Result on the web

<a href="http://dx.doi.org/10.1016/j.jns.2017.03.035" target="_blank" >http://dx.doi.org/10.1016/j.jns.2017.03.035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2017.03.035" target="_blank" >10.1016/j.jns.2017.03.035</a>

Result language

angličtina

Original language name

Permeability surface area product analysis in malignant brain edema prediction – A pilot study

Original language description

Background and purpose Using an extended CT perfusion acquisition (150s), we sought to determine the association between perfusion parameters and malignant edema after ischemic stroke. Methods Patients (from prospective study PROVE-IT, NCT02184936) with terminal internal carotid artery +- proximal middle cerebral occlusion were involved. CTA was assessed for clot location and status of leptomeningeal collaterals. The following CTP parameters were calculated within the ischemic territory and contralaterally: permeability surface area product (PS), cerebral blood flow (CBF) and cerebral blood volume (CBV). PS was calculated using the adiabatic approximation to the Johnson and Wilson model. Outcome was evaluated by midline shift and infarction volume on follow-up imaging. Results Of 200 patients enrolled, 7 patients (3.5%) had midline shift GREATER-THAN OR EQUAL TO 5 mm (2 excluded for poor-quality scans). Five patients with midline shift and 5 matched controls were analysed. There was no significant difference in mean PS, CBF and CBV within the ischemic territory between the two groups. A CBV threshold of 1.7 ml/100 g had the highest AUC = 0.72, 95% CI = 0.54-0.90 for early midline shift prediction, sensitivity and specificity were 0.83 and 0.67 respectively. Conclusion Our preliminary results did not show significant differences in permeability surface area analysis if analysed for complete ischemic region. CBV parameter had the highest accuracy and there was a trend for the mean PS values for midline shift prediction.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

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Volume of the periodical

376

Issue of the periodical within the volume

MAY

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

206-210

UT code for WoS article

000401210500043

EID of the result in the Scopus database

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