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Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066929" target="_blank" >RIV/00159816:_____/17:00066929 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/17:00095409

  • Result on the web

    <a href="http://dx.doi.org/10.1002/anie.201611193" target="_blank" >http://dx.doi.org/10.1002/anie.201611193</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/anie.201611193" target="_blank" >10.1002/anie.201611193</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites

  • Original language description

    The enzymatic enantiodiscrimination of linear beta-haloalkanes is difficult because the simple structures of the substrates prevent directional interactions. Herein we describe two distinct molecular mechanisms for the enantiodiscrimination of the beta-haloalkane 2-bromopentane by haloalkane dehalogenases. Highly enantioselective DbjA has an open, solvent-accessible active site, whereas the engineered enzyme DhaA31 has an occluded and less solvated cavity but shows similar enantioselectivity. The enantioselectivity of DhaA31 arises from steric hindrance imposed by two specific substitutions rather than hydration as in DbjA.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Angewandte Chemie-International Edition

  • ISSN

    1433-7851

  • e-ISSN

  • Volume of the periodical

    56

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    4719-4723

  • UT code for WoS article

    000398576000004

  • EID of the result in the Scopus database