Interictal brain activity differs in migraine with and without aura: resting state fMRI study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066963" target="_blank" >RIV/00159816:_____/17:00066963 - isvavai.cz</a>

Result on the web

<a href="https://thejournalofheadacheandpain.springeropen.com/articles/10.1186/s10194-016-0716-8" target="_blank" >https://thejournalofheadacheandpain.springeropen.com/articles/10.1186/s10194-016-0716-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s10194-016-0716-8" target="_blank" >10.1186/s10194-016-0716-8</a>

Result language

angličtina

Original language name

Interictal brain activity differs in migraine with and without aura: resting state fMRI study

Original language description

Background: Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we examined amplitude, the resting state fMRI fluctuation in migraineurs with and without aura (MWA, MWoA respectively) and healthy controls. Methods: Resting state functional MRI images and T1 high-resolution images were acquired from all participants. For data analysis we compared the groups (MWA-Control, MWA-MWoA, MWoA-Control). The resting state networks were identified by MELODIC. The mean time courses of the networks were identified for each participant for all networks. The time-courses were decomposed into five frequency bands by discrete wavelet decomposition. The amplitude of the frequency-specific activity was compared between groups. Furthermore, the preprocessed resting state images were decomposed by wavelet analysis into five specific frequency bands voxel-wise. The voxel-wise amplitudes were compared between groups by non-parametric permutation test. Results: In the MWA-Control comparison the discrete wavelet decomposition found alterations in the lateral visual network. Higher activity was measured in the MWA group in the highest frequency band (0.16-0.08 Hz). In case of the MWA-MWoA comparison all networks showed higher activity in the 0.08-0.04 Hz frequency range in MWA, and the lateral visual network in in higher frequencies. In MWoA-Control comparison only the default mode network revealed decreased activity in MWoA group in the 0. 08-0.04 Hz band. The voxel-wise frequency specific analysis of the amplitudes found higher amplitudes in MWA as compared to MWoA in the in fronto-parietal regions, anterior cingulate cortex and cerebellum.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Headache and Pain

ISSN

1129-2369

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

JAN

Country of publishing house

IT - ITALY

Number of pages

9

Pages from-to

8

UT code for WoS article

000397741200001

EID of the result in the Scopus database

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