Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067248" target="_blank" >RIV/00159816:_____/17:00067248 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10373877 RIV/00064203:_____/17:10373877

Result on the web

<a href="http://dx.doi.org/10.1155/2017/6364314" target="_blank" >http://dx.doi.org/10.1155/2017/6364314</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2017/6364314" target="_blank" >10.1155/2017/6364314</a>

Result language

angličtina

Original language name

Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Original language description

Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer&apos;s disease (AD) already at the stage of mild cognitive impairment (MCI). We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC). In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions. We observed reductions of intrinsic activity in MCI patients. We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F = 4 44, p = 0 05), pallidum (F = 8 97, p = 0 005), and thalamus (F = 5 95, p = 0 02), which were negative in NC (right hippocampus, r = -0 49; right pallidum, r = -0 50; right thalamus, r = -0 45; all p &lt; 0 05) but absent in MCI (right hippocampus, r = 0 21; right pallidum, r = 0 32; right thalamus r = 0 28; all p &gt; 0 2). These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Neurology

ISSN

0953-4180

e-ISSN

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Volume of the periodical

2017

Issue of the periodical within the volume

2017

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

6364314

UT code for WoS article

000412005300001

EID of the result in the Scopus database

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