Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067533" target="_blank" >RIV/00159816:_____/17:00067533 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098773 RIV/65269705:_____/17:00067533

Result on the web

<a href="http://dx.doi.org/10.1002/mds.26930" target="_blank" >http://dx.doi.org/10.1002/mds.26930</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mds.26930" target="_blank" >10.1002/mds.26930</a>

Result language

angličtina

Original language name

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Original language description

Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Movement disorders

ISSN

0885-3185

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

757-768

UT code for WoS article

000401936200018

EID of the result in the Scopus database

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