Post-radiation cognitive inpairment and hippocampal neuronal depletion measured by in-vivo metabolic MR spectroscopy: Results of prospective investigational study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068395" target="_blank" >RIV/00159816:_____/17:00068395 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/neuonc/nox036.170" target="_blank" >http://dx.doi.org/10.1093/neuonc/nox036.170</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/neuonc/nox036.170" target="_blank" >10.1093/neuonc/nox036.170</a>
Alternative languages
Result language
angličtina
Original language name
Post-radiation cognitive inpairment and hippocampal neuronal depletion measured by in-vivo metabolic MR spectroscopy: Results of prospective investigational study
Original language description
Hippocampal radioinjury-mediated cognitive impairment is currently widely investigated in many preclinical and clinical trials. Further studying of hippocampal pathophysiological changes after radiation and its relation to memory alteration are still needed to enable critical evidence for introduction hippocampal sparing and/or drug intervention for preserving memory function. For confirmation of this concept, a deeper understanding of the correlations of imaging and functional changes is needed. The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate it to neurocognitive dysfunction
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů