Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068406" target="_blank" >RIV/00159816:_____/17:00068406 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00100125

Result on the web

<a href="http://dx.doi.org/10.1161/STROKEAHA.117.018223" target="_blank" >http://dx.doi.org/10.1161/STROKEAHA.117.018223</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/STROKEAHA.117.018223" target="_blank" >10.1161/STROKEAHA.117.018223</a>

Result language

angličtina

Original language name

Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis

Original language description

Background and Purpose-Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction. We aimed to determine which baseline clinical and radiological parameters predict development of CED in patients treated with intravenous thrombolysis. Methods-We used an image-based classification of CED with 3 degrees of severity (less severe CED 1 and most severe CED 3) on postintravenous thrombolysis imaging scans. We extracted data from 42 187 patients recorded in the SITS International Register (Safe Implementation of Treatments in Stroke) during 2002 to 2011. We did univariate comparisons of baseline data between patients with or without CED. We used backward logistic regression to select a set of predictors for each CED severity. Results-CED was detected in 9579/42 187 patients (22.7%: 12.5% CED 1, 4.9% CED 2, 5.3% CED 3). In patients with CED versus no CED, the baseline National Institutes of Health Stroke Scale score was higher (17 versus 10; P&lt;0.001), signs of acute infarct was more common (27.9% versus 19.2%; P&lt;0.001), hyperdense artery sign was more common (37.6% versus 14.6%; P&lt;0.001), and blood glucose was higher (6.8 versus 6.4 mmol/L; P&lt;0.001). Baseline National Institutes of Health Stroke Scale, hyperdense artery sign, blood glucose, impaired consciousness, and signs of acute infarct on imaging were independent predictors for all edema types. Conclusions-The most important baseline predictors for early CED are National Institutes of Health Stroke Scale, hyperdense artery sign, higher blood glucose, decreased level of consciousness, and signs of infarct at baseline. The findings can be used to improve selection and monitoring of patients for drug or surgical treatment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Stroke

ISSN

0039-2499

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

2464-"+"

UT code for WoS article

000408438000045

EID of the result in the Scopus database

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