MicroRNAs Involvement in Radioresistance of Head and Neck Cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068981" target="_blank" >RIV/00159816:_____/17:00068981 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/17:00095643 RIV/00209805:_____/17:00077827
Result on the web
<a href="https://www.hindawi.com/journals/dm/2017/8245345/" target="_blank" >https://www.hindawi.com/journals/dm/2017/8245345/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2017/8245345" target="_blank" >10.1155/2017/8245345</a>

Result language
angličtina
Original language name
MicroRNAs Involvement in Radioresistance of Head and Neck Cancer
Original language description
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/NV15-31627A" target="_blank" >NV15-31627A: Molecularly guided radiotherapy or radiochemotherapy based on mikroRNA profile in head and neck cancer patients- a feasibility study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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