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Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068623" target="_blank" >RIV/00159816:_____/18:00068623 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26310/17:PU127108 RIV/68081707:_____/18:00491698 RIV/00216224:14310/18:00102399

  • Result on the web

    <a href="https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf" target="_blank" >https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.snb.2017.12.108" target="_blank" >10.1016/j.snb.2017.12.108</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes

  • Original language description

    The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)(2)) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)(2) and P3HT were stable but PEDOT: PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)(2) and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)(2), P3HT and PEDOT:PSS.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    SENSORS AND ACTUATORS B-CHEMICAL

  • ISSN

    0925-4005

  • e-ISSN

  • Volume of the periodical

    260

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    8

  • Pages from-to

    418-425

  • UT code for WoS article

    000424884300050

  • EID of the result in the Scopus database