Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068623" target="_blank" >RIV/00159816:_____/18:00068623 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/17:PU127108 RIV/68081707:_____/18:00491698 RIV/00216224:14310/18:00102399
Result on the web
<a href="https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf" target="_blank" >https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2017.12.108" target="_blank" >10.1016/j.snb.2017.12.108</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes
Original language description
The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)(2)) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)(2) and P3HT were stable but PEDOT: PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)(2) and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)(2), P3HT and PEDOT:PSS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SENSORS AND ACTUATORS B-CHEMICAL
ISSN
0925-4005
e-ISSN
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Volume of the periodical
260
Issue of the periodical within the volume
May
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
418-425
UT code for WoS article
000424884300050
EID of the result in the Scopus database
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