Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068652" target="_blank" >RIV/00159816:_____/18:00068652 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/ane.12880" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/ane.12880</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ane.12880" target="_blank" >10.1111/ane.12880</a>
Alternative languages
Result language
angličtina
Original language name
Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis
Original language description
Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS-EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD-10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0-1) at 3months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24hours after IVT. Results Data of 13772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3years, respectively (P<.001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points - in atherothrombotic stroke, 7 points - in lacunar stroke, and 10 pointsin other stroke types (P<.001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR=1.63 (95% CI: 1.07-2.47), P=.023], lower odds of early improvement [OR=0.79 (95% CI: 0.72-0.86), P<.001], and excellent clinical outcome [OR=0.77 (95% CI: 0.67-0.87), P<.001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta neurologica Scandinavica
ISSN
0001-6314
e-ISSN
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Volume of the periodical
137
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
347-355
UT code for WoS article
000424092700010
EID of the result in the Scopus database
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