Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068806" target="_blank" >RIV/00159816:_____/18:00068806 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00103968 RIV/65269705:_____/18:00068806

Result on the web

<a href="https://www.dovepress.com/influence-of-dose-gender-and-cigarette-smoking-on-clozapine-plasma-con-peer-reviewed-fulltext-article-NDT" target="_blank" >https://www.dovepress.com/influence-of-dose-gender-and-cigarette-smoking-on-clozapine-plasma-con-peer-reviewed-fulltext-article-NDT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S163839" target="_blank" >10.2147/NDT.S163839</a>

Result language

angličtina

Original language name

Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Original language description

Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric disease and treatment

ISSN

1178-2021

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

JUN 2018

Country of publishing house

NZ - NEW ZEALAND

Number of pages

9

Pages from-to

1535-1543

UT code for WoS article

000435877800001

EID of the result in the Scopus database

2-s2.0-85048719752